Job Details

About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Using Stoke's proprietary approach, the company is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

STK-002 is Stoke's proprietary antisense oligonucleotide (ASO) in clinical development for the treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. STK-002 has been granted orphan drug designation by the FDA. A Phase 1 study (OSPREY) of STK-002 in people with ADOA is now underway. The company is also conducting early research in Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Stoke's initial focus is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach.

Position Purpose:

The Senior Manager, Program Management is a flexible execution-enablement role within the Program Management function, designed to strengthen program management capability, infrastructure, and day-to-day execution support across internal teams.

The Senior Manager plays a critical role in driving program success by partnering closely with the lead Program Manager and the extended Program Team. Acting as a PM force multiplier, this role delivers hands-on project management support, strengthens PM ways of working, and builds scalable tools and processes by providing targeted expertise where it's most needed to enable integrated planning and team cohesion

This role offers significant growth through exposure to alliance program execution, cross-functional development work and PM capability building in a fast-moving biotech environment.

This position plays a pivotal role in enabling sub-teams and external partners to operate as high-performing execution engines, complementing the lead Program Managers' integration and strategic Program Team leadership to ensure seamless delivery and alignment

This position will report into the Director, Program Management/Program Team Lead PM.

Key Responsibilities:

Project Management Enablement & Sub-team Support

• Provide hands-on project management support to sub-team leads and sub-team managers to strengthen planning, tracking, and execution.
• Support teams in applying core PM disciplines (e.g., work planning, milestone tracking, issue escalation, dependency awareness).
• Act as a trusted PM advisor to teams that do not have dedicated PM capacity, helping improve consistency and execution rigor.

Execution Tracking & Risk Awareness

• Support tracking of milestones, actions, risks, and issues as needed across the sub-team and Program Team (in partnership with the Lead PM).
• Proactively surface execution risks, gaps, or misalignment to the Program Manager for integration and escalation.
• Help teams prepare clear inputs and updates as needed, to support efficient Program Team and governance discussions.

PM Capability and Infrastructure Building

• Build, maintain, and continuously improve program management infrastructure including timelines, trackers, dashboards, templates, SharePoint sites and reporting tools, while contributing to the evolution of the function through scalable tools, templates, and processes.
• Support consistent application of PM standards, tools, and best practices across sub-teams and alliance workstreams.
• Ensure data quality, version control, and clarity of ownership across PM artifacts.
• Support onboarding and enablement of team members into PM processes and tools.

Communication, Synthesis & Clarity

• Draft clear, concise written materials (e.g., summaries, trackers, updates, pre-reads) that enable efficient review and follow-up.
• Facilitate clear communication across sub-teams and working groups, ensuring decisions, actions, and next steps are well understood.
• Bring structure and clarity to ambiguous or evolving execution challenges.

Required Skills & Experience:

Required

• Bachelor's degree (preferably in a scientific, engineering, or related field); advanced degree a plus.
• 3-5+ years of experience in project or program management within biotech, pharmaceutical, or life sciences organizations.
• Experience supporting cross-functional
• Strong written and verbal communication skills, with the ability to synthesize information and drive clarity.
• Demonstrated ability to operate flexibly, manage multiple priorities, and adapt to evolving needs.
• Experience in building PM capability, tools, and ways of working.
• Proficient in PM tools such as MS Project, SmartSheets, OnePager, etc.

Preferred

• Familiarity with clinical development processes and development governance.
• Experience supporting working in alliance-based or partner-driven development models.
• PMP or equivalent certification (or progress toward certification).

Location(s):

Stoke is located in Bedford, MA. This position is a hybrid position with an office setting based in Bedford, MA location.

Travel:

This position will require approximately 10% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $174,000 - $202,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center:



For more information, visit

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.